Shingles, also known as zoster or herpes zoster, is a viral infection caused by the varicella zoster virus (VZV), the same virus that causes chickenpox.

Anyone who's had chickenpox can get shingles. After you've been infected with chickenpox, the varicella zoster virus lies inactive in your body — mostly in spinal or cranial nerves — usually for many decades. If the virus reactivates, it can travel along nerve pathways to your skin and cause a painful rash to erupt.

Shingles is very rarely life-threatening, but it can be exceedingly painful. It’s been on the rise in the United States for the last couple of decades, according to the Centers for Disease Control and Prevention (CDC), though doctors aren’t sure why.

If you’re over 50 or over 18 and immunocompromised, you can get a shingles vaccine to prevent it.

Signs and Symptoms of Shingles

Shingles usually appears as a single stripe of blisters around the left or right side of the body. Less commonly, it can occur on one side of the face. It is almost always unilateral, meaning it involves only one side of the body.

But you can get a shingles rash anywhere: on your feet, your buttocks, your legs, even your genital area, according to a case report led by Anne Louise Oaklander, MD, PhD, an associate professor of neurology at Harvard Medical School and the director of the nerve unit and skin biopsy lab at Massachusetts General Hospital in Boston.

Is That Rash by My Eye Really Shingles?

Shingles tends to show up most frequently on the torso, just because of the laws of probability, notes Joseph Safdieh, MD, a professor of neurology at Weill Cornell Medicine in New York City. In that area of your body, there are 24 nerves that can host the virus, compared with the 10 in your lower back.

Often, it’s not what the rash looks like, but what it feels like before and after it shows up, that signals the condition. Up to several days before the shingles rash appears, pain, itching, or tingling often occurs in the area where it will develop.

In the days before the rash appears, a variety of other flu-like symptoms of shingles can occur. You may experience:

  • Chills
  • Fever
  • Headache
  • Upset stomach

You may even experience the pain but not the rash. Because the pain of shingles originates in the nerves, it may have a different quality than any other pain you may have experienced before.

“Neuropathic pain is burning,” says Dr. Safdieh. “It’s both numb and painful at the same time, and can be provoked by touching the skin.” Your skin may be so sensitive that even sunlight can bring on a stabbing sensation.

Even if you aren’t sure you have shingles, you should still see a doctor right away, because immediate treatment can prevent complications like long-term nerve pain.

Learn More About the Signs and Symptoms of Shingles

Causes and Risk Factors of Shingles

The varicella zoster virus — the virus that causes chickenpox and shingles — is part of a group of viruses called herpes viruses. This group also includes the viruses that cause cold sores (oral herpes) and genital herpes.

But the varicella zoster virus is not the same virus that causes cold sores and genital herpes. The viruses that cause oral and genital herpes are herpes simplex 1 and herpes simplex 2.

If you’ve had chickenpox, you can get shingles. After the chickenpox is over, varicella zoster lies inactive, mainly in spinal or cranial nerves. Sometimes the virus reactivates, and that’s when it travels along the nerves to erupt as a rash on your skin, causing shingles.

But the cause of the reactivation is still unknown, according to the National Institute of Neurological Disorders and Stroke.

Risk Factors

The risk of shingles increases as you age, which may be due to lowered immunity to infections as you grow older.

The following may also put you at increased risk for shingles, according to the CDC.
  • Certain cancers, such as leukemia and lymphoma
  • HIV or AIDS
  • Immunosuppressive medications, such as corticosteroids, which are used in the treatment of cancer and autoimmune conditions like rheumatoid arthritis, as well as drugs that are given to people who have undergone an organ transplant
Some research suggests that genetics may play a part, according to MedlinePlus.If you have a first-degree relative — meaning a parent or sibling — who has had shingles, it may increase your risk of having it. A study published in the Journal of Clinical Virology found that nearly 44 percent of those with shingles had family members who had also developed it.

Is Stress a Risk Factor for Shingles?

You may have heard that someone got shingles because they were stressed, perhaps after the death of a relative, soon after a divorce, or at the end of a difficult semester at school.

But studies haven’t definitively proved that stress is a risk factor for shingles. Some research suggests that it is, according to MedlinePlus, while other research suggests that it’s not at all.
In a study published in March 2015 in Clinical Infectious Diseases, researchers reviewed the medical records of more than 39,000 people to see if cases of shingles increased after a difficult life event, and the authors found no evidence that stress is a trigger.

“There’s some controversy about the matter,” says Safdieh. “We know for a fact that stress can have an impact on the function of the immune system. If there’s stress, immunity is depressed, and I certainly see patients who tell me they were having a lot of stress when they got shingles.” But, he adds, “there are many people who are stressed and don’t get shingles, and many people who get them while they’re on vacation.”

If there is a link between stress and shingles, it’s probably not that the stress itself is putting a strain on the immune system — it may be that stress creates conditions that lower immunity. “Keep in mind,” says Safdieh, “that when you’re stressed, you don’t sleep and you don’t eat, and all these factors can play a role.”

RELATED: How Stress Affects Your Body, From Your Brain to Your Digestive System

Prognosis of Shingles

It's uncommon to have shingles more than once, however, it's possible to get it two or more times.

In a study published in the journal Mayo Clinic Proceedings, the overall recurrence rate for shingles was 6.2 percent.But for those whose immune systems were compromised, the rate was almost twice that. The authors of the Mayo Clinic paper also note that recurrences were more likely in women, in those older than 50, and in those who’d experienced shingles-related pain for 30 days or longer during their initial episode.

Why do people get shingles more than once? “Usually it's because immunity to zoster — and other infections — normally wanes over time,” explains Dr. Oaklander. “When you have chickenpox or shingles, it boosts your immunity for the next decade or so, but if you were immunosuppressed when you contracted the chickenpox or shingles, you might not mount a robust immunity and you could get it again.”

She adds that those who are immunosuppressed because of medication or illness, such as cancer or HIV, sometimes develop prolonged, repeated, or chronic zoster infections. “That's why it's critical for people to get immunized before they get old, sick, or start immunosuppressive medication,” she says.

Treatment and Medication Options for Shingles

There’s no cure for shingles, but if you get immediate treatment, it can help speed the healing process and reduce your risk of complications.

Medication Options

Your physician may prescribe an antiviral drug, such as Valtrex (valacyclovir), to treat the rash, in addition to other drugs if you are experiencing pain, notes the CDC.Antivirals can help shorten the duration and severity of shingles and are most effective if you start them as quickly as possible after the rash appears.

Prescription or over-the-counter (OTC) pain medication may also bring relief. And if you’re 50 or older or over 18 and immunocompromised, you can receive a shingles vaccine once the disease has run its course.

Alternative and Complementary Therapies

Home remedies such as oatmeal baths can temporarily alleviate itching. Wet compresses and calamine lotion may also help soothe skin symptoms.

Learn More About Treating Shingles

Prevention of Shingles

The U.S. Food and Drug Administration (FDA) approved recombinant zoster vaccine, known as Shingrix, for adults ages 50 years old and older in 2017. In July 2021, the FDA also approved Shingrix for adults ages 18 years old and older who are or will be at increased risk of herpes zoster due to immunodeficiency or immunosuppression caused by disease or therapy, according to a press release issued by Shingrix manufacturer GlaxoSmithKline (GSK). In October 2021, the CDC's Advisory Committee on Immunization Practices (ACIP) also voted to recommend Shingrix in adults 19 years of age and older who are or will be immunodeficient or immunosuppressed due to disease or therapy, according to a press release issued by GSK.

RELATED: CDC Committee Gives Green Light to Shingles Vaccine for Immunocompromised Adults

Sales of an older, live vaccine, Zostavax, were discontinued in July 2020. Even if you’ve already had shingles, received Zostavax, or aren't sure whether you ever had chickenpox, you should get Shingrix, per the CDC.
Shingles can’t be passed between people, but the varicella zoster virus can spread to people who aren't immune to chickenpox — meaning those who have not been vaccinated against chickenpox or have not had the disease.

The varicella zoster virus can spread from person to person through direct contact with the open sores of the shingles rash when blisters are present. It can also be spread by airborne droplets in people with a primary VZV infection.

Once infected for the first time, the person will develop chickenpox, not shingles.

If the rash is covered, the risk of a person with shingles spreading the virus to others is low.

But chickenpox can be dangerous for some groups of people, including premature or low birth weight infants, pregnant women who have never had chickenpox or the chickenpox vaccine, and anyone who has a weakened immune system.

So until your shingles blisters turn into scabs, you'll be able to pass the virus on to others and you should therefore avoid contact with those who could be harmed by catching chickenpox.

The following steps can help keep you from spreading the virus:

  • Keep the rash covered.
  • Avoid touching or scratching the rash.
  • Wash your hands often.

Research and Statistics: Who Gets Shingles?

Almost 1 out of every 3 people in the United States will develop shingles at some point, according to the CDC.
There are an estimated one million U.S. cases of shingles each year. About 1 out of 100 U.S. shingles cases occur in people age 60 or older.
In fact, about half of people over 80 have had shingles, notes MedlinePlus.

The chickenpox vaccine was introduced in 1995 and has reduced incidence of the virus by up to 85 percent. Theoretically, this should reduce the incidence of shingles as people who were vaccinated as children grow up, but it's too soon to know if this is the case.

Resources We Love

Essential Organizations for Shingles Information

National Institute of Neurological Disorders and Stroke (NINDS)

Along with clear, comprehensive info about shingles — what it is and how it's treated — the NINDS provides updates on research looking into why the virus reactivates and efforts to better understand what leads to ongoing pain. The NINDS site also includes links to current clinical trials.

NIH National Library of Medicine Genetics Home Reference

Here you'll find a focus on the role of genetics in shingles. Research has suggested that certain genes may be associated with whether people develop shingles or post-herpetic neuropathy.

Neuropathy Commons

Shingles — including post-herpetic neuralgia and post-herpetic itch — is among the conditions that the Nerve Unit at Massachusetts General Hospital treats and studies. Their website, Neuropathy Commons, is dedicated to helping patients find neuropathy experts and resources in their area. In addition to a searchable database of neurologists who specialize in neuropathy, the site has links to patient stories and support groups.

Favorite Podcast for Shingles Info 

Shingles: What You Should Know About the Sequel to Chickenpox

For an informative, accessible discussion on shingles — that you can listen to just about anywhere — check out an episode of this podcast from Cleveland Clinic's Health Essentials podcast.

Learn More About Additional Resources and Support for Shingles

Editorial Sources and Fact-Checking

  • Shingles Burden and Trends. Centers for Disease Control and Prevention. August 14, 2019.
  • Oaklander AL, Rissmiller JG. Postherpetic Neuralgia After Shingles: An Under-Recognized Cause of Chronic Vulvar Pain. Obstetrics & Gynecology. April 2002.
  • Shingles: Hope Through Research. National Institute of Neurological Disorders and Stroke. March 23, 2020.
  • Shingles (Herpes Zoster) Transmission. Centers for Disease Control and Prevention. July 1, 2019.
  • Shingles. MedlinePlus. August 18, 2020.
  • Hernadez PO, Javed S, Mendoza N, et al. Family History and Herpes Zoster Risk in the Era of Shingles Vaccination. Journal of Clinical Virology. December 2011.
  • Harpaz R, Leung JW, Brown CJ, Zhou FJ. Psychological Stress as a Trigger for Herpes Zoster: Might the Conventional Wisdom Be Wrong? Clinical Infectious Diseases. March 2015.
  • Shingles (Herpes Zoster) Diagnosis & Testing. Centers for Disease Control and Prevention. September 19, 2019.
  • Yawn BP, Wollan PC, Kurland MJ, et al. Herpes Zoster Recurrences More Frequent Than Previously Reported. Mayo Clinic Proceedings. February 2011.
  • Shingles (Herpes Zoster) Clinical Overview. Centers for Disease Control and Prevention. October 5, 2020.
  • Johnson RW, Alvarez-Pasquin MJ, Bijl M, et al. Herpes Zoster Epidemiology, Management, and Disease and Economic Burden in Europe: A Multidisciplinary Perspective. Therapeutic Advances in Vaccines and Immunotherapy. July 2015.
  • Treating Shingles. Centers for Disease Control and Prevention. July 1, 2019.
  • Shingles Vaccination. Centers for Disease Control and Prevention. January 25, 2018.
  • Complications of Shingles. Centers for Disease Control and Prevention. July 1, 2019.
  • Management of Herpes Zoster (Shingles) During Pregnancy. Journal of Obstetrics and Gynaecology. October 2018.
  • Chickenpox (Varicella) for Healthcare Professionals. Centers for Disease Control and Prevention. April 28, 2021.


Please enter your comment!
Please enter your name here